Cellulose Derived Hydrocolloids and Microcrystalline Cellulose


Cellulose derivatives cover the range of modified celluloses approved as food additives. These are methyl cellulose E461 (MC) and hydroxypropyl methylcellulose E464 (HPMC), used for binding and shape retention, film formation and barrier properties, and avoidance of boil-out and bursting at higher temperatures; hydroxypropyl cellulose E463 (HPC), which presents good surface activity exploited in the use of lower viscosity grades of toppings for whipping or dispensing from aerosol cans; methyl ethyl cellulose E465 (MEC), and sodium carboxymethyl cellulose E466 (CMC), for viscosity improvement. The raw material for modified celluloses is cellulose pulp, which in turn is produced from wood pulp from specified species or cotton linters. Drug-excipient interactions: FEX Form I was separately mixed in 1:1 ratios with sodium carbonate, mannitol, magnesium stearate, colloidal anhydrous silica, povidone K90, crospovidone, and hydroxypropyl methylcellulose. The blends were stored at 40 °C/75% relative humidity and 65 °C for 30 days. In the case of drug–the sodium carbonate mixture at 40 °C/75% RH, a liquefaction tendency was observed, with a reduction in enthalpy value (ΔH) of FEX peak at 200–205 °C in DSC and a concomitant decrease in assay value. No evidence for instability was noted with other excipients, indicating their compatibility with FEX. If you are looking for high quality, high purity, and cost-effective Hydroxypropyl methylcellulose, or if you require the latest price of Hydroxypropyl methylcellulose, please feel free to email contact mis-asia.

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