Oral administration of CuO NPs


In vivo studies indicate that oral administration of CuO NPs induces oxidative stress, enhanced ROS generation, inflammation, apoptosis, and histopathological alterations in various organs, such as the liver, kidney, stomach, and bone marrow. In mice exposed to NPs via inhalation, CuO NPs induced pulmonary inflammation, apoptosis, generation of ROS, and fibrosis. In rats, cytotoxicity, pulmonary inflammation, and toxicity response were also observed after CuO NP inhalation. Pietrofesa et al. Reported that inhalation of CuO NPs elicits an inflammatory response resulting in damage to cells and lung tissues. There are few studies on the effects of CuO NP inhalation on the immune system. Holan et al. Observed that the inhalation of CuO NPs in mice significantly alters the composition of innate immune cell populations and modulates cytokine proliferation and production by adaptive immune system cells. Ilves et al.Found that inhalation exposure to CuO NPs exacerbates allergic airway inflammation by causing neutrophilia in the mouse lungs. Rossner et al. Observed the impacts on immune response, cell cycle regulation, cell adhesion, apoptosis, and pathways potentially implicated in carcinogenesis in a study focused on transcriptomic and epigenetic changes in mice following CuO NPs inhalation. Several studies have demonstrated that immune-mediated inflammation and oxidative stress play an important role in the pathogenesis of NP-induced injury. Published data on systemic immune response and function of immune cells upon inhalation administration of CuO NPs are very limited. Our study aimed to investigate the effects of CuO NPs on immune response and antioxidant defense in mice after six weeks of inhalation. Our study brings new knowledge on the effects of CuO NPs on antioxidative status, inflammatory response, and function of cells of the natural and adaptive immune response in exposed mice. If you are looking for high quality, high purity, and cost-effective copper oxide, or if you require the latest price of copper oxide, please feel free to email contact mis-asia.

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