Hardships in vaccine preservation time in history
Proposal and experiment of siliconized vaccine
In the latest research progress, the researchers mailed two copies of tetanus vaccine from the University of Bath to Newcastle University by mail (the distance between the two places is 300 miles, and the delivery takes one or two days). One vaccine "wears a silica coat"; the other is unprotected. After the delivery, it was found that the "silicified" vaccine was successfully injected into the mouse to trigger an immune response. This situation indicates that the vaccine is active; while the vaccine without protection measures injected into the mouse did not trigger the immune response, indicating that the vaccine has been It was damaged during transportation.
Wonderful combination of silica and protein
When the protein in the solution is mixed with silica, the silica is tightly bound to the protein to match its shape, and quickly forms a multi-layer cage to wrap the protein. Compared with similar technologies, the biggest advantage of this method is that it does not require freeze-drying, and about half of the vaccine will be damaged at this time.
Once the protein is combined with silica, it can be stored or transported without freezing. It is worth noting that the outer layer of silica can be chemically removed, and the activity of the released protein is not affected.
Dr. Issel Satabava, the head of the latest research and the Department of Chemistry at the University of Bath, said: "The research results are exciting. This new technology not only protects the protein structure of the vaccine, but also retains its function-the immunogen Sex."
Sata Bava explained: "Our current focus is on tetanus vaccine, which is part of the DTP vaccine (diphtheria, tetanus and pertussis) vaccinated by children. Next, we will work to develop heat-stable diphtheria and Pertussis vaccine. Ultimately, we want to'siliconize' the triple vaccine of the entire DTP system so that every child can get the DTP vaccine without relying on cold chain transportation."
Planning the future development of vaccines
It is reported that as a result of exposure to suboptimal temperatures, up to 50% of the vaccine is discarded before use. Data from the World Health Organization show that in 2018, 19.4 million babies were not vaccinated.