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Advanced functional materials: design a multiplier to induce "immunogenic death" of cancer cells to enhance the systemic immune clearance of tumors

The characteristics of

cancer such as easy metastasis difficult to cure high recurrence guide the current high-efficiency treatment scheme to clear solid tumors but also wake up the anti-cancer immune monitoring of patients. Induction of immunogenic death of cancer cells can stimulate the autoimmune system achieve lasting anti-cancer immunity. Inspired by this a large number of studies on immunogenic cell death have been reported in recent ten years. Among them chemotherapy radiotherapy commonly used in clinic have such inducing effect. Unfortunately the weak induction ability severe damage of healthy tissue limit the promotion of this kind of therapy to tumor immunotherapy. Fenton reagent can catalyze the accumulation of hydrogen peroxide in tumor area to produce highly cytotoxic reactive oxygen species (e.g. · Oh 1O2 O2 · -) which can induce cancer cell death without harming healthy organs tissues. More importantly studies have found that when the concentration of reactive oxygen species in cancer cells is higher than the toxic threshold dose it will induce immunogenic death. Therefore providing sufficient reactive oxygen species in cancer cells may significantly improve the efficiency of such immune induction.

Dr. Li Bei Professor Xu Zhiping senior lecturer of millet University of New South Wales Australia Institute of bioengineering nanotechnology University of Queensl jointly designed a new hydrotalcite based hybrid nano tablet to solve the problem of how to significantly improve the immunogenic mortality of cancer cells( FeOOH@STA/Cu-LDH )。 The FeOOH nanoparticles synthesized by them are only 3-5 nm in size have the characteristics of high efficient Fenton reaction can be uniformly immobilized on the layered double hydroxides (layered double hydroxides) Cu LDH. The near-infrared photothermal conversion ability of Cu LDH sheet carrier can not only increase the microenvironment temperature induce cancer cell death by hyperthermia but also increase the Fenton reaction efficiency to about 5 times of the original generate a large number of reactive oxygen species. After systematic verification heat shock protein inhibitor sta-9090 was used to reduce the lethal temperature of cancer cells to a temperature range similar to high fever (40-42 ℃). Therefore the hybrid nanosheets can effectively combine the characteristics of near-infrared photothermal conversion Fenton reaction achieve the maximization of “immunogenic death” of cancer cells that is the function of “immunogenic death” multiplier of cancer cells. Interestingly in vivo mouse 4T1 double tumor model experiment the hybrid material was only used for hyperthermia to treat the left tumor which basically eliminated the left tumor significantly inhibited the growth of the right remote tumor for a long time. These results fully confirm the conclusion FeOOH@STA/Cu-LDH The systemic tumor clearance rate was 0. The authors of

believe that this study confirms the excellent feasibility of a combination of mild therapies that stimulate the body’s immune response in the treatment of metastatic or undetected cancers.

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