Oral administration of CuO NPs
In vivo studies indicate that oral administration of CuO NPs induces oxidative stress, enhanced ROS generation, inflammation, apoptosis, and histopathological alterations in various organs, such as the liver, kidney, stomach, and bone marrow. In mice exposed to NPs via inhalation, CuO NPs induced pulmonary inflammation, apoptosis, generation of ROS, and fibrosis. In rats, cytotoxicity, pulmonary inflammation, and toxicity response were also observed after CuO NP inhalation. Pietrofesa et al. Rep