First, Do No Harm
Until a way is found to update system files that are open, reboots will be necessary. Making those reboots less painful is the next best step--and hardware and software optimization is helping, with boot times now approaching 30 seconds on some modern systems. In the end, computers need to take care of themselves without disrupting our work; protecting our work before running updates is a great way to start.
Sign up for MIS Asia eNewsletters.