Not that the thumb buttons are well-placed to begin with. They're arranged on the left corner of the Daedalus Apex's diamond, with one to the rear and one to the front of said corner. The rear side button is fine—your thumb presses against it like normal.
But the front side button? Pushing it involves pulling the thumb back in, toward the palm. It's not a very ergonomic motion, nor is it easy to execute without simultaneously shifting the mouse by a few millimeters.
Last but not least, we should complain a bit about the scroll wheel. It's coated in a slick rubber instead of the usual tire tread-esque grip, and it has a tendency to shift forward or backward whenever you try to click Middle Mouse—the same problem I had with its sibling, the G502.
I'm not a big fan. The G303 Daedalus Apex is outfitted like a premium mouse, with a dreamboat 12,000 DPI sensor and some of the nicest Left/Right mouse buttons I've had the pleasure of clicking. And Logitech's RGB lighting is, as per usual, beautifully handled—bright and accurate, with a pleasant honeycomb pattern.
That shape though. It's so awkward. I was excited to put the G303 through its paces because it's rare we get a mouse designed specifically for claw-grippers, but the Daedalus Apex feels like it needs (more than) a few revisions.
The one use case I can think of: People with smaller-than-average hands. Most gaming mice seem designed for giants. The G303 Daedalus Apex is one of the few that seems like it would work for those with daintier digits.
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