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AIE and black phosphorus nanomaterials join forces to fight cancer cells

As one of the most important diseases threatening human health in the world, cancer has attracted the attention of researchers. Among the many advances made in the past few decades, cancer therapeutics has skillfully integrated precise diagnosis and targeted therapy into a single platform that coexists in space. Compared with traditional small molecule formulations, the nano-therapeutic platform has great potential in achieving the maximization of therapeutic efficiency and the minimization of off-target toxicity. Previously developed treatment systems showed their own and common shortcomings, including poor diagnostic imaging quality, low therapeutic load and storage stability, toxicity and non-degradability of intrinsic components, and production complexity. In view of the specific circumstances, exploring a multifunctional nano-therapy platform with good biocompatibility, good diagnostic imaging and therapeutic effects has become an urgent need for tumor treatment.
Recently, Academician Tang Benzhong and Associate Professor Wang Dong of Shenzhen University published a communication titled "Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics" on Advanced Materials. They are affected by aggregation-induced emission (AIE) activity. Inspired by the respective advantages of photosensitizers and black phosphorous nanomaterials in cancer treatment, the simple construction of a new type of AIE photosensitizer combined with two-dimensional black phosphorous nanosheets and its application in multi-modal therapy were demonstrated. The developed nanomaterials also have excellent stability, good biocompatibility, strong fluorescence emission in the near-infrared region, high-performance active oxygen generation, good light-to-heat conversion efficiency, excellent cell absorption and other characteristics and A variety of functions, and effective accumulation in the tumor site. Both in vitro and in vivo evaluations show that the nano imaging system is an excellent candidate for near-infrared fluorescence-photothermal dual imaging guided synergistic photodynamic-photothermal therapy. This research not only expands the application range of AIE and black phosphorus materials, but also provides useful insights for designing a new generation of cancer treatment programs.
The author successfully developed the combination of AIEgen and two-dimensional black phosphorus nanosheets for the first time. The hybrid nano material has high stability and good biocompatibility, can effectively generate active oxygen, has strong FR/NIR fluorescence and good photothermal conversion efficiency. These remarkable features make it have remarkable performance in cancer treatment in vitro and in vivo, including NIR FLI-PTI dual imaging guided and coordinated PDT-PTT. This example of successful multimodal therapy will provide a blueprint for the next generation of effective treatment systems for cancer treatment.

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