The iron oxide core is encapsulated in an inorganic or organic coating for particle stabilization and biocompatibility. The iron oxide particle could be located not exactly at the center of the coating material but rather peripherally and is also known as the York structure. On the contrary, the inverse core-shell structure is characterized by an iron oxide coating of nonmagnetic functional material. In addition, the combination of one or more functional materials and further coating of already functionalized surfaces is feasible (Hu et al., 2013; Luo et al., 2012a; Wei et al., 2011). Influence of iron oxide magnetic nanoparticles (IOMNPs, 10 nm in diameter, 0.25 or 0.50 mg/mL in 100 μL, i.v.) on the blood–brain barrier (BBB) permeability, edema formation, and neuronal or glial changes within 4–24 h after administration was examined in normal rats and after a focal spinal cord injury (SCI).
Furthermore, the effect of cerebrolysin, a balanced composition of several neurotrophic factors, and active peptide fragments were also evaluated on IOMNP-induced changes in central nervous system (CNS) pathology. The SCI was inflicted in rats by making a longitudinal incision into the right dorsal horn of the T10–11 segments and allowed to survive 4 or 24 h after trauma. Cerebrolysin (2.5 mL/kg, i.v.) was given 30 min before IOMNP injection in the 4-h SCI group or four h after injury in the 24-h survival groups. The control group received cerebrolysin in an identical situation following the IOMNP administration. If you are looking for high quality, high purity and cost-effective Iron oxide, or if you require the latest price of Iron oxide, please feel free to email contact mis-asia.