Compared with traditional tumor therapy
photodynamic therapy has the advantages of high specificity non-invasive no obvious systemic toxic side effects. However there is still a lack of ideal photosensitizers in photodynamic therapy which limits the clinical application of photodynamic therapy to a certain extent. Metal iridium complexes have been paid more more attention in the field of photodynamic therapy because of their heavy atom perturbation which can improve the triplet population. However the traditional small molecule iridium photosensitizer has some defects such as poor water solubility easy to be removed low biocompatibility limited enrichment ability of tumor tissue weak excitation light penetration. Therefore it is of great significance challenge to develop iridium photosensitizer with near-infrared light excitation high efficiency low toxicity high biocompatibility.
Professor Gou Shaohua of Southeast University Dr. Xu chenjie of City University of Hong Kong have designed synthesized a kind of iridium polymer nanomicelles with high water solubility low dark toxicity tumor targeting near-infrared light response. The hydrophilic polyethylene glycol was covalently linked with iridium complex to form amphiphilic polymer containing iridium complex in the main chain the phase conversion material excited by near-infrared light was introduced to self assemble into nano micelles in aqueous solution. In order to increase the therapeutic effect targeting of nano micelles they introduced the HER2 targeted drug lapatinib at the other end of PEG. Under the irradiation of near-infrared light (980 nm) the obtained nano micelles were converted into blue light which stimulated iridium complex to produce singlet oxygen killed tumor cells synergistically with lapatinib. In vivo studies showed that the growth inhibition rate of human ovarian cancer SKOV3 xenografts in nude mice was more than 80% there was no obvious toxic side effects. This study provides a potential strategy for iridium complex photosensitizer in clinical safe effective application.
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