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Controlled Release of Curcumin from HPMC Co Spray Dried Materials

What is Hydroxypropyl methyl cellulose?

Hydroxypropyl methylcellulose is a white, odorless, tasteless powder made chemically through the modification of cellulose. Cellulose is a natural polymer – long chains or structures of many molecules strung together. It is used as a vegan alternative to gelatine in medicines and supplements, as a treatment for dry eye syndrome, and as a gluten replacement in gluten-free bread. Gluten-free bread improves elasticity, stability, volume, and moisture retention. This makes a loaf more akin to gluten-containing bread (source: Study on effects of HPMC and CMC on the properties of gluten-free bread).

 

Is it safe to eat?

Humans cannot digest hydroxypropyl methylcellulose, which passes through the digestive system. In the UK, it was submitted by Dow (who manufactures HPMC for the global food market) for approval to the Advisory Committee on Novel Foods and Processes in November 2011. It is now an EU and FDA-approved food additive and is considered non-toxic to humans. Moreover, for gluten-free food manufacturers, it must be a godsend. Softer bread, fewer holes, good color, greater volume. Everything you want in bread! However, many people have contacted me to say they cannot eat food containing it. I have also found several forums online where people have made the connection between bloating, wind, and discomfort in eating foods (or supplements) that contain it. If you are on a gluten-free diet but still experiencing tummy discomfort, it might be worth checking whether this is in your food. You might also like to join my gluten-free diet course, where I help explore ingredients that may be causing ongoing symptoms.

 

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methylcellulose) was spray-dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N2 adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.

 

Price of Hydroxypropyl methyl cellulose

Hydroxypropyl methyl cellulose particle size and purity will affect the product's Price, and the purchase volume can also affect the cost of Hydroxypropyl methyl cellulose. A large amount of large amount will be lower. The Price of Hydroxypropyl methyl cellulose is on our company's official website.

 

Hydroxypropyl methyl cellulose supplier

Mis-Asia is a reliable and high-quality global chemical material supplier and manufacturer. It has over 12 years of experience providing ultra-high quality chemicals and nanotechnology materials, including Hydroxypropyl methyl cellulose, nitride powder, graphite powder, sulfide powder, and 3D printing powder. If you are looking for high-quality and cost-effective Hydroxypropyl methyl cellulose, you are welcome to contact us or inquire any time.

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